Brain structural imaging correlates of olfactory dysfunction in obsessive-compulsive disorder

C Segalàs; P Alonso; A Orbegozo; E Real; M Subirà; C López-Solà; I Martínez-Zalacaín; J Labad; BJ Harrison; J Pujol; JM Menchón; N Cardoner; C Soriano-Mas

Journal article

Brain structural imaging correlates of olfactory dysfunction in obsessive-compulsive disorder

C Segalàs, P Alonso, A Orbegozo, E Real, M Subirà, C López-Solà, I Martínez-Zalacaín, J Labad, BJ Harrison, J Pujol, JM Menchón, N Cardoner, C Soriano-Mas

European Archives of Psychiatry and Clinical Neuroscience | SPRINGER HEIDELBERG | Published : 2014

DOI: 10.1007/s00406-013-0439-7

Abstract

Olfactory dysfunction has been described in obsessive-compulsive disorder (OCD). Brain regions involved in smell processing partially overlap with structures included in the neurobiological models of OCD, although no previous studies have analyzed the neuroanatomical correlates of olfactory dysfunction in this disorder. The aim of our study was to examine the association between regional gray matter volume, as assessed by a voxel-based morphometry analysis of magnetic resonance images (MRI), and olfactory function, as assessed by the Sniffin' Sticks test (SST). Olfactory function was assessed in 19 OCD patients and 19 healthy volunteers. All participants were also scanned in a 1.5-T magnet t..

View full abstract

University of Melbourne Researchers

Ben Harrison Author

Related Projects (1)

Specific Brain Networks Related to the Symptoms of Obsessive-Compulsive Disorder

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported in part by the Carlos III Health Institute (PI09/01331 PI10/01753, PI10/01003, CP10/00604, CIBER-CB06/03/0034) and by the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR; 2009SGR1554). Dr. Soriano-Mas is funded by a "Miguel Servet" contract from the Carlos III Health Institute (CP10/00604). Eva Real is supported by a "Rio Hortega" contract from the Carlos III Health Institute (I.D. CM11/00077). Marta Subira is funded by a pre-doctoral grant from the Bellvitge Biomedical Research Institute (IDIBELL). Clara Lopez is supported by a pre-doctoral grant from the Ministry of Education, Culture and Sport (FPU12/01636). Dr. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I.D. 628509). We thank Gerald Fannon for revising the manuscript.